抄録
Clostridium species belonging to clusters XIVa and IV are predominant organisms in the gut microbiota. They are known to affect various aspects of host biology, including the optimal breakdown of foods, competition with pathogenic microorganisms, maintenance of the intestinal epithelial barrier, and immune system development. We have recently shown that a defined mixture of 46 strains of mouse-derived Clostridium species belonging to clusters XIVa and IV affects the development and function of colonic Foxp3+ CD4+ regulatory T (Treg) cells in mice. Clostridium-induced Treg cells are likely to play a role in the maintenance of immune homeostasis in the gut.
| 本文言語 | English |
|---|---|
| ホスト出版物のタイトル | Innate Immunity |
| ホスト出版物のサブタイトル | Resistance and Disease-Promoting Principles |
| 出版社 | S. Karger AG |
| ページ | 43-47 |
| ページ数 | 5 |
| 巻 | 4 |
| ISBN（電子版） | 9783318023480 |
| ISBN（印刷版） | 9783318023473 |
| DOI | |
| 出版ステータス | Published - 2013 6月 5 |
ASJC Scopus subject areas
- 医学（全般）
- 免疫学および微生物学（全般）
- 生化学、遺伝学、分子生物学（全般）