Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel

Ambara R. Pradipta; Ayumi Tsutsui; Akihiro Ogura; Shinya Hanashima; Yoshiki Yamaguchi; Almira Kurbangalieva; Katsunori Tanaka

doi:10.1055/s-0034-1378634

Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel

Ambara R. Pradipta
, Ayumi Tsutsui
, Akihiro Ogura
, Shinya Hanashima
, Yoshiki Yamaguchi
, Almira Kurbangalieva
, Katsunori Tanaka

研究成果: Article › 査読

20 被引用数 (Scopus)

抄録

The [4+4] polymerization of an unsaturated imine, generated from the condensation of a polyamine and excess acrolein, was investigated. The polyamine was added by micropipet to acrolein, immediately yielding a mixture of the immiscible polymeric material. Microfluidic mixing was used to gradually form the soluble diazacyclooctane polymers. The polymerization reaction ultimately gave an insoluble cationic hydrogel that adhered strongly to anionic compounds on cell surfaces, including sialoglycan, and displayed a high cytotoxicity.

本文言語	English
論文番号	st-2014-u0541-l
ページ（範囲）	2442-2446
ページ数	5
ジャーナル	Synlett
巻	25
号	17
DOI	https://doi.org/10.1055/s-0034-1378634
出版ステータス	Published - 2014 10月 22
外部発表	はい

ASJC Scopus subject areas

有機化学

文献へのアクセス

10.1055/s-0034-1378634

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フィンガープリント

「Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Pradipta, A. R., Tsutsui, A., Ogura, A., Hanashima, S., Yamaguchi, Y., Kurbangalieva, A., & Tanaka, K. (2014). Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel. Synlett, 25(17), 2442-2446. 記事 st-2014-u0541-l. https://doi.org/10.1055/s-0034-1378634

Pradipta, AR, Tsutsui, A, Ogura, A, Hanashima, S, Yamaguchi, Y, Kurbangalieva, A & Tanaka, K 2014, 'Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel', Synlett, vol. 25, no. 17, st-2014-u0541-l, pp. 2442-2446. https://doi.org/10.1055/s-0034-1378634

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abstract = "The [4+4] polymerization of an unsaturated imine, generated from the condensation of a polyamine and excess acrolein, was investigated. The polyamine was added by micropipet to acrolein, immediately yielding a mixture of the immiscible polymeric material. Microfluidic mixing was used to gradually form the soluble diazacyclooctane polymers. The polymerization reaction ultimately gave an insoluble cationic hydrogel that adhered strongly to anionic compounds on cell surfaces, including sialoglycan, and displayed a high cytotoxicity.",

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