Modulation of immune responses by DNA damage signaling

Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Atsushi Shibata

研究成果: Article査読

9 被引用数 (Scopus)

抄録

An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses.

本文言語English
論文番号103135
ジャーナルDNA Repair
104
DOI
出版ステータスPublished - 2021 8月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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