Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Mari Hosonaga, Hideyuki Saya, Yoshimi Arima

研究成果: Review article査読

63 被引用数 (Scopus)


Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are at high risk for the development of brain metastases. Despite recent advances in the treatment of primary breast tumors, the prognosis of breast cancer patients with brain metastases remains poor. A better understanding of the molecular and cellular mechanisms underlying brain metastasis might be expected to lead to improvements in the overall survival rate for these patients. Recent studies have revealed complex interactions between metastatic cancer cells and their microenvironment in the brain. Such interactions result in the activation of various signaling pathways related to metastasis in both cancer cells and cells of the microenvironment including astrocytes and microglia. In this review, we focus on such interactions and on their role both in the metastatic process and as potential targets for therapeutic intervention.

ジャーナルCancer and Metastasis Reviews
出版ステータスPublished - 2020 9月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


「Molecular and cellular mechanisms underlying brain metastasis of breast cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。