Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima; Masashi Hasegawa; Junji Shimizu; Shuichi Matsumura

Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima, Masashi Hasegawa, Junji Shimizu, Shuichi Matsumura

応用化学科

研究成果: Article › 査読

9 被引用数 (Scopus)

抄録

The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

本文言語	English
ページ（範囲）	28-35
ページ数	8
ジャーナル	Arkivoc
巻	2004
号	13
出版ステータス	Published - 2004 8月 23

ASJC Scopus subject areas

有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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引用スタイル

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AU - Shimizu, Junji

AU - Matsumura, Shuichi

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N2 - The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

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KW - Anthracene

KW - Carbohydrate

KW - Cytotoxicity

KW - DNA cleavage

KW - Photoirradiation

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