TY - GEN
T1 - Molecular robotics approach for constructing an artificial cell model
AU - Nomura, Shin Ichiro M.
AU - Sato, Yusuke
AU - Fujiwara, Kei
N1 - Funding Information:
We would like to thank Prof. S. Murata and S. Hamada for their insightful comments. This work was supported by
Funding Information:
1 Tohoku University, 6-6-01, Aramaki Aza-aoba, Aoba-ku, Sendai, Japan 2 JSPS Research Fellowship for Young Scientists [email protected]
Publisher Copyright:
© 2013 Proceedings of the 12th European Conference on the Synthesis and Simulation of Living Systems: Advances in Artificial Life, ECAL 2013. All rights reserved.
PY - 2013
Y1 - 2013
N2 - Prototype artificial cell models with designed functional molecules are presented here. Artificial molecular devices based on a giant liposome were prepared to obtain specific properties that cannot be obtained from natural cells. In this context, artificial cell research is seen an extension of "molecular robotics" research. Cooperative and integrated chemical systems will be constructed from the molecular devices. Here, we present the 3 aspects of the study model: (1) geneexpressing cell model encapsulated in the liposome to simulate membrane protein synthesis, (2) multirole molecular device with a designed DNA nanostructure on the cellular membrane, and (3) designed membrane peptide device for surface recognition. Although these devices are inspired by living cell functions, such goaloriented systems are free from the constraints of natural history and evolution. These artificial devices may be integrated to develop novel tools for living systems.
AB - Prototype artificial cell models with designed functional molecules are presented here. Artificial molecular devices based on a giant liposome were prepared to obtain specific properties that cannot be obtained from natural cells. In this context, artificial cell research is seen an extension of "molecular robotics" research. Cooperative and integrated chemical systems will be constructed from the molecular devices. Here, we present the 3 aspects of the study model: (1) geneexpressing cell model encapsulated in the liposome to simulate membrane protein synthesis, (2) multirole molecular device with a designed DNA nanostructure on the cellular membrane, and (3) designed membrane peptide device for surface recognition. Although these devices are inspired by living cell functions, such goaloriented systems are free from the constraints of natural history and evolution. These artificial devices may be integrated to develop novel tools for living systems.
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U2 - 10.7551/978-0-262-31709-2-ch070
DO - 10.7551/978-0-262-31709-2-ch070
M3 - Conference contribution
AN - SCOPUS:85152617713
T3 - Proceedings of the 12th European Conference on the Synthesis and Simulation of Living Systems: Advances in Artificial Life, ECAL 2013
SP - 488
EP - 491
BT - Proceedings of the 12th European Conference on the Synthesis and Simulation of Living Systems
PB - MIT Press Journals
T2 - 12th European Conference on the Synthesis and Simulation of Living Systems: Advances in Artificial Life, ECAL 2013
Y2 - 2 September 2013 through 6 September 2013
ER -