Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi; Keisuke Ichinohe; Shinya Kida; Shinya Murase; Osamu Yamada; Yoshiteru Oshima

doi:10.1021/acs.orglett.6b03057

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi
, Keisuke Ichinohe
, Shinya Kida
, Shinya Murase
, Osamu Yamada
, Yoshiteru Oshima

研究成果: Article › 査読

33 被引用数 (Scopus)

抄録

A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

本文言語	English
ページ（範囲）	5948-5951
ページ数	4
ジャーナル	Organic Letters
巻	18
号	22
DOI	https://doi.org/10.1021/acs.orglett.6b03057
出版ステータス	Published - 2016 11月 18
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/acs.orglett.6b03057

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引用スタイル

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