TY - JOUR
T1 - Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice
AU - Iwata, Hiroki
AU - Tsuchiya, Shizuko
AU - Ueno, Koichi
AU - Nakamura, Tomonori
AU - Yano, Shingo
PY - 2008/12/14
Y1 - 2008/12/14
N2 - It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.
AB - It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.
KW - Circular muscle contraction
KW - Morphine
KW - Morphine-3-glucuronide
KW - Morphine-6-glucuronide
KW - Mouse ileum
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U2 - 10.1016/j.ejphar.2008.10.009
DO - 10.1016/j.ejphar.2008.10.009
M3 - Article
C2 - 18930729
AN - SCOPUS:55949093717
SN - 0014-2999
VL - 600
SP - 130
EP - 132
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 1-3
ER -