TY - JOUR
T1 - Motobamide, an Antitrypanosomal Cyclic Peptide from a Leptolyngbya sp. Marine Cyanobacterium
AU - Takahashi, Hiroki
AU - Iwasaki, Arihiro
AU - Kurisawa, Naoaki
AU - Suzuki, Ryota
AU - Jeelani, Ghulam
AU - Matsubara, Teruhiko
AU - Sato, Toshinori
AU - Nozaki, Tomoyoshi
AU - Suenaga, Kiyotake
N1 - Funding Information:
This work was supported by JSPS KAKENHI (Grant Numbers 18K14346 and 20H02870).
Publisher Copyright:
© 2021 American Chemical Society and American Society of Pharmacognosy.
PY - 2021/5/28
Y1 - 2021/5/28
N2 - Motobamide (1), a new cyclic peptide containing a C-prenylated cyclotryptophan residue, was isolated from a marine Leptolyngbya sp. cyanobacterium. Its planar structure was established by spectroscopic and MS/MS analyses. The absolute configuration was elucidated based on a combination of chemical degradations, chiral-phase HPLC analyses, spectroscopic analyses, and computational chemistry. Motobamide (1) moderately inhibited the growth of bloodstream forms of Trypanosoma brucei rhodesiense (IC50 2.3 μM). However, it exhibited a weaker cytotoxicity against normal human cells (IC50 55 μM).
AB - Motobamide (1), a new cyclic peptide containing a C-prenylated cyclotryptophan residue, was isolated from a marine Leptolyngbya sp. cyanobacterium. Its planar structure was established by spectroscopic and MS/MS analyses. The absolute configuration was elucidated based on a combination of chemical degradations, chiral-phase HPLC analyses, spectroscopic analyses, and computational chemistry. Motobamide (1) moderately inhibited the growth of bloodstream forms of Trypanosoma brucei rhodesiense (IC50 2.3 μM). However, it exhibited a weaker cytotoxicity against normal human cells (IC50 55 μM).
UR - http://www.scopus.com/inward/record.url?scp=85106463723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106463723&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.1c00234
DO - 10.1021/acs.jnatprod.1c00234
M3 - Article
C2 - 33983736
AN - SCOPUS:85106463723
SN - 0163-3864
VL - 84
SP - 1649
EP - 1655
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
