Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation

Kato Tamotsu, Fukuda Shinji, Fujiwara Akemi, Suda Wataru, Hattori Masahira, Kikuchi Jun, Ohno Hiroshi, Osamu Ohara

研究成果: Article査読

72 被引用数 (Scopus)


Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, L-phenylalanine, L-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.

ジャーナルDNA Research
出版ステータスPublished - 2014 10月 1

ASJC Scopus subject areas

  • 医学一般


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