抄録
Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1355-1359 |
| ページ数 | 5 |
| ジャーナル | Journal of Cell Science |
| 巻 | 115 |
| 号 | 7 |
| 出版ステータス | Published - 2002 4月 1 |
ASJC Scopus subject areas
- 細胞生物学