@article{74bd0ee12cf64cea9b5fe37e45001a75,
title = "Musashi and Seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development",
abstract = "We have examined the roles played by the Drosophila neural RNA-binding protein Musashi (MSI) in eye development. MSI expression was observed in the nuclei of all photoreceptor cells (R1-R8). Although a msi loss-of-function mutation resulted in only weak abnormalities in photoreceptor differentiation, we found that the msi eye phenotype was significantly enhanced in a seven in absentia (sina) background. sina is known to be involved in the degradation of the Tramtrack (TTK) protein, leading to the specification of the R7 fate. We demonstrated that MSI also functions to regulate TTK expression. The sina msi mutants showed significantly high ectopic expression of TTK69 and failure in the determination of the R1, R6, and R7 fates. Other photoreceptor cells also failed to differentiate with abnormalities occurring late in the differentiation process. These results suggest that MSI and SINA function redundantly to downregulate TTK in developing photoreceptor cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.",
keywords = "Drosophila, Eye development, Musashi, Photoreceptor cell, RNA-binding protein, Seven in absentia, Tramtrack",
author = "Yuki Hirota and Masataka Okabe and Takao Imai and Mitsuhiko Kurusu and Atsuyo Yamamoto and Sachiyo Miyao and Makoto Nakamura and Kazunobu Sawamoto and Hideyuki Okano",
note = "Funding Information: We would like to thank Ritsuko Shimamura for technical assistance, and Yasushi Hiromi, Daisuke Yamamoto, Kaoru Saigo, Mathew Freeman, Christian Kl{\"a}mbt, Andrew Traverse, the Developmental Studies Hybridoma Bank, and the Bloomington Stock Center for supplying the fly stocks and/or antibodies. This work was supported by grants from the Japanese Ministry of Science, Education, Sports and Culture to H.O. H.O. was supported by the Human Frontier Science Program Organization and CREST, Japan Science and Technology Corporation. T. Imai was supported by the Japan Society for the Promotion of Science.",
year = "1999",
month = sep,
day = "1",
doi = "10.1016/S0925-4773(99)00143-4",
language = "English",
volume = "87",
pages = "93--101",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}