TY - JOUR
T1 - MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus
AU - Lang, Karl
AU - Navarini, Alexander A.
AU - Recher, Mike
AU - Lang, Philipp A.
AU - Heikenwalder, Mathias
AU - Stecher, Barbara
AU - Bergthaler, Andreas
AU - Odermatt, Bernhard
AU - Akira, Shizuo
AU - Honda, Kenya
AU - Hengartner, Hans
AU - Zinkernagel, Rolf M.
PY - 2007/9
Y1 - 2007/9
N2 - MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88-/- mice. We found an increased susceptibility to VSV in myd88-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
AB - MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88-/- mice. We found an increased susceptibility to VSV in myd88-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
KW - Inflammation
KW - Toll-like receptor
KW - Vesicular stomatitis
KW - Virus
UR - https://www.scopus.com/pages/publications/34548737204
UR - https://www.scopus.com/pages/publications/34548737204#tab=citedBy
U2 - 10.1002/eji.200737310
DO - 10.1002/eji.200737310
M3 - Article
C2 - 17668900
AN - SCOPUS:34548737204
SN - 0014-2980
VL - 37
SP - 2434
EP - 2440
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 9
ER -