TY - JOUR
T1 - Nanoparticles
T2 - A promising modality in the treatment of sarcomas
AU - Susa, Michiro
AU - Milane, Lara
AU - Amiji, Mansoor M.
AU - Hornicek, Francis J.
AU - Duan, Zhenfeng
N1 - Funding Information:
This project was supported, in part, by a grant from the National Cancer Institute, NIH (Nanotechnology Platform Partnership), R01-CA119617. Dr. Duan is supported, in part, through a grant from the Sarcoma Foundation of America. Support has also been provided by the Gattegno and Wechsler funds.
PY - 2011/2
Y1 - 2011/2
N2 - Improvements in surgical technique, chemotherapy, and radiotherapy have enhanced the prognosis of sarcoma patients, but have since reached a plateau in recent years. Novel approaches have been sought but with limited results. Nanomedicine offers solutions in diverse areas of sarcoma therapy including diagnosis and treatment. Several varieties of nanoparticles, including multifunctional nanoparticles, are available that localize the biodistribution of conventional chemotherapeutics to the tumor site. Also, nanoparticles loaded with chemotherapeutic drugs have the ability to overcome drug resistance which is a major obstacle impeding the progress of the treatment. Multifunctional nanoparticles, which have the potential to further augment the bioavailability of drugs, are being actively investigated. In this review, we will discuss the application of nanoparticles for improving the treatment of sarcoma patients.
AB - Improvements in surgical technique, chemotherapy, and radiotherapy have enhanced the prognosis of sarcoma patients, but have since reached a plateau in recent years. Novel approaches have been sought but with limited results. Nanomedicine offers solutions in diverse areas of sarcoma therapy including diagnosis and treatment. Several varieties of nanoparticles, including multifunctional nanoparticles, are available that localize the biodistribution of conventional chemotherapeutics to the tumor site. Also, nanoparticles loaded with chemotherapeutic drugs have the ability to overcome drug resistance which is a major obstacle impeding the progress of the treatment. Multifunctional nanoparticles, which have the potential to further augment the bioavailability of drugs, are being actively investigated. In this review, we will discuss the application of nanoparticles for improving the treatment of sarcoma patients.
KW - cancer-initiating cell
KW - drug resistance
KW - nanoparticle
KW - sarcoma
KW - tyrosine kinase
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U2 - 10.1007/s11095-010-0173-z
DO - 10.1007/s11095-010-0173-z
M3 - Review article
C2 - 20505985
AN - SCOPUS:79952478409
SN - 0724-8741
VL - 28
SP - 260
EP - 272
JO - Pharmaceutical research
JF - Pharmaceutical research
IS - 2
ER -
