Renal excretion mechanisms of panipenem (PAPM) and betamipron (BP) in rabbit were investigated by clearance techniques in vivo. The renal clearance (CLr) of PAPM under steady state exhibited 1 to 1.5-fold of glomerular filtration rate (GFR) and significantly decreased by the concomitant dose of BP. Similar decrement of CLr was found after treatment of some organic anions, probenecid or iodopyracet, but not p-aminohippuric acid. Organic cations such as N1-methylnicotinamide and tetraethylammonium did not affect on the renal excretion of PAPM. BP and probenecid remarkably inhibited their CLr each other. Stop-flow analysis confirmed that both PAPM and BP were predominately secreted from renal proximal tubule. Concomitant intravenous dose of BP decreased the urinary excretion rate constant of cephaloridine (CER) and cephalexin (CEX) without any change of other pharmacokinetic parameters.
|Published - 1991 1月 1
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