Neural crest-derived stem cells display a wide variety of characteristics

Narihito Nagoshi, Shinsuke Shibata, Masaya Nakamura, Yumi Matsuzaki, Yoshiaki Toyama, Hideyuki Okano

研究成果: Review article査読

38 被引用数 (Scopus)


A recent burst of findings has shown that neural crest-derived stem cells (NCSCs) can be found in diverse mammalian tissues. In addition to their identification in tissues that are known to be derived from the neural crest, recent studies have revealed NCSCs in tissues that are not specifically derived from the neural crest, such as bone marrow. NCSCs can express a wide range of characteristics, and which properties are expressed mainly depends on their tissue sources and the ontogenic stage of the animal. The identification of NCSCs in various tissues opens an entirely new avenue of approach to developing autologous cell replacement therapies for use in regenerative medicine. In this review, we discuss the origin, migration, and lineage potential of NCSCs from various mammalian tissue sources.

ジャーナルJournal of Cellular Biochemistry
出版ステータスPublished - 2009 8月 15

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学


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