TY - JOUR
T1 - New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation
AU - Kikuchi, Haruhisa
AU - Hoshi, Tomoko
AU - Kitayama, Minoru
AU - Sekiya, Mizuki
AU - Katou, Yasuhiro
AU - Ueda, Kazunori
AU - Kubohara, Yuzuru
AU - Sato, Hiroki
AU - Shimazu, Mitsuaki
AU - Kurata, Shoichiro
AU - Oshima, Yoshiteru
N1 - Funding Information:
We are grateful to Ms. K. Nakata, and Y. Hasegawa for their technical assistance. This work was supported in part by Grant-in-Aid for Scientific Research (Nos. 18710179, 18032013, 19310135, 18·5061) from the Ministry of Education, Science, Sports and Culture of Japan; Program for Promotion of Basic Research Activities for Innovative BioSciences; and Chugai Pharmaceutical Co., Ltd.
PY - 2009/1/10
Y1 - 2009/1/10
N2 - To date, entomopathogenic fungi have not been extensively examined by natural product chemists. In this study, we isolated novel pyrone diterpene-type compounds, metarhizins A (1) and B (2), from methanol extracts of entomopathogenic fungus, Metarhizium flavoviride. They showed potent and selective antiproliferative activity against both insect and human cancer cell lines. These results indicate that metarhizins A (1) and B (2) can be used as novel lead compounds for anti-cancer agents and probes for cell cycle regulation. To further investigate the structural requirements for this inhibitory activity, we synthesized many metarhizin derivatives and evaluated their antiproliferative activities.
AB - To date, entomopathogenic fungi have not been extensively examined by natural product chemists. In this study, we isolated novel pyrone diterpene-type compounds, metarhizins A (1) and B (2), from methanol extracts of entomopathogenic fungus, Metarhizium flavoviride. They showed potent and selective antiproliferative activity against both insect and human cancer cell lines. These results indicate that metarhizins A (1) and B (2) can be used as novel lead compounds for anti-cancer agents and probes for cell cycle regulation. To further investigate the structural requirements for this inhibitory activity, we synthesized many metarhizin derivatives and evaluated their antiproliferative activities.
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U2 - 10.1016/j.tet.2008.11.014
DO - 10.1016/j.tet.2008.11.014
M3 - Article
AN - SCOPUS:56949097895
SN - 0040-4020
VL - 65
SP - 469
EP - 477
JO - Tetrahedron
JF - Tetrahedron
IS - 2
ER -
