TY - JOUR
T1 - New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou
AU - Fuchino, Hiroyuki
AU - Kiuchi, Fumiyuki
AU - Yamanaka, Azusa
AU - Obu, Akihiro
AU - Wada, Hiroshi
AU - Mori-Yasumoto, Kanami
AU - Kawahara, Nobuo
AU - Flores, Diana
AU - Palacios, Olga
AU - Sekita, Setsuko
AU - Satake, Motoyoshi
PY - 2013/9
Y1 - 2013/9
N2 - Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9μg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6μg/mL, respectively).
AB - Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9μg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6μg/mL, respectively).
KW - Barbasco
KW - Leguminosae
KW - Leishmania
KW - Lonchocarpus nicou
KW - Peruvian folk medicine
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UR - http://www.scopus.com/inward/citedby.url?scp=84884894573&partnerID=8YFLogxK
U2 - 10.1248/cpb.c13-00385
DO - 10.1248/cpb.c13-00385
M3 - Article
C2 - 23995361
AN - SCOPUS:84884894573
SN - 0009-2363
VL - 61
SP - 979
EP - 982
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 9
ER -