TY - JOUR
T1 - New neurons clear the path of astrocytic processes for their rapid migration in the adult brain
AU - Kaneko, Naoko
AU - Marín, Oscar
AU - Koike, Masato
AU - Hirota, Yuki
AU - Uchiyama, Yasuo
AU - Wu, Jane Y.
AU - Lu, Qiang
AU - Tessier-Lavigne, Marc
AU - Alvarez-Buylla, Arturo
AU - Okano, Hideyuki
AU - Rubenstein, John L.R.
AU - Sawamoto, Kazunobu
N1 - Funding Information:
We thank the anonymous reviewers for helpful comments on the manuscript; Dr. Fujio Murakami for providing the specific antibodies to Robo1 and Robo2; Dr. Didier Trono for providing the lentivirus packaging plasmids, psPAX2 and pMD2.G; Dr. Nathaniel Heintz and the Mutant Mouse Regional Resource Center (MMRRC) for providing the Gfap-EGFP mice; and Drs. Ichiro Miyoshi, Tatsumi Hirata, Francois Renault-Mihara and Takehiko Sunabori and Miss Rie Ueda for technical support. This work was supported by research grants from the Ministry of Education, Culture, Sports, Science & Technology (MEXT), Ministry of Health, Labor and Welfare (MHLW), Japan Society for the Promotion of Science (JSPS), Human Frontier Science Program (HFSP), Toray Science Foundation, Keio University Medical Science Fund, Inoue Foundation for Science, NOVARTIS Foundation (Japan) for the Promotion of Science, and Kowa Life Science Foundation. J.Y.W is supported by NIH (CA114197, CA107193) and James S. McDonnell Foundation. N.K. was an Inoue Fellow.
PY - 2010/7
Y1 - 2010/7
N2 - In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.
AB - In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.
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U2 - 10.1016/j.neuron.2010.06.018
DO - 10.1016/j.neuron.2010.06.018
M3 - Article
C2 - 20670830
AN - SCOPUS:77955490391
SN - 0896-6273
VL - 67
SP - 213
EP - 223
JO - Neuron
JF - Neuron
IS - 2
ER -