New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida; Yuka Furuno; Seiichiro Ogawa

doi:10.1039/C39890001230

New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida
, Yuka Furuno
, Seiichiro Ogawa

応用化学科

研究成果: Article › 査読

28 被引用数 (Scopus)

抄録

A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

本文言語	English
ページ（範囲）	1230-1231
ページ数	2
ジャーナル	Journal of the Chemical Society D: Chemical Communications
号	17
DOI	https://doi.org/10.1039/C39890001230
出版ステータス	Published - 1989

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分子医療

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10.1039/C39890001230

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abstract = "A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.",

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AB - A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

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New synthesis of (+)-and (-)-nojirimycin from myo-inositol

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