Newer Insights Into Fetal Growth and Body Composition

Satoru Ikenoue, Yoshifumi Kasuga, Toyohide Endo, Mamoru Tanaka, Daigo Ochiai

研究成果: Review article査読

2 被引用数 (Scopus)


Based on epidemiological and experimental evidence, the origins of childhood obesity and early onset metabolic syndrome can be extended back to developmental processes during intrauterine life. It is necessary to actively investigate antecedent conditions that affect fetal growth by developing reliable measures to identify variations in fetal fat deposition and body composition. Recently, the resolution of ultrasonography has remarkably improved, which enables better tissue characterization and quantification of fetal fat accumulation. In addition, fetal fractional limb volume has been introduced as a novel measure to quantify fetal soft tissue volume, including fat mass and lean mass. Detecting extreme variations in fetal fat deposition may provide further insights into the origins of altered fetal body composition in pathophysiological conditions (i.e., fetal growth restriction or fetal macrosomia), which are predisposed to the metabolic syndrome in later life. Further studies are warranted to determine the maternal or placental factors that affect fetal fat deposition and body composition. Elucidating these factors may help develop clinical interventions for altered fetal growth and body composition, which could potentially lead to primary prevention of the future risk of metabolic dysfunction.

ジャーナルFrontiers in Endocrinology
出版ステータスPublished - 2021 7月 22

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学


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