Non-thermal ablation technology for arrhythmia therapy: Acute and chronic electrical conduction block with photosensitization reaction

Arisa Ito, Hiroki Matsuo, Tsukasa Suenari, Takuro Kajihara, Takehiro Kimura, Shunichiro Miyoshi, Tsunenori Arai

研究成果: Conference contribution

2 被引用数 (Scopus)


We have examined the possibility of non-thermal ablation technology for arrhythmia therapy with photosensitization reaction, in which photochemically generated singlet molecular oxygen may induce myocardial electrical conduction block. In the most popular energy source for arrhythmia catheter ablation; radiofrequency current, the thermal tissue injury causes electrophysiological disruption resulting in electrical isolation of ectopic beats. The temperature-mediated tissue disruption is difficult to control because the tissue temperature is determined by the heating and thermal conduction process, so that severe complications due to excessive heat generation have been the problem in this ablation. We demonstrated the electrical conduction block of surgically exposed porcine heart tissue in vivo with photosensitization reaction. The acute myocardial electrical conduction block was examined by the stimulation and propagation set-up consisting of a stimulation electrode and two bipolar measurement electrodes. Fifteen to thirty minutes after the injection of 5-10 mg/kg water-soluble chlorine photosensitizer, Talaporfin sodium (NPe6, LS11), the laser light at the wavelength of 663 nm with the total energy density of 50-200 J/cm2 was irradiated several times with 3- 7 mm in spot-size to make electrical block line in myocardial tissue across the conduction pathway between the bipolar measurement electrodes. The propagation delay time of the potential waveform increased with increasing the irradiated line length. The observation of Azan-stained specimens in the irradiated area two weeks after the procedure showed that the normal tissue was replaced to the scar tissue, which might become to be permanent tissue insulation. These results demonstrated the possibility of non-thermal electrical conduction block for arrhythmia therapy by the photosensitization reaction.

ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics VI
出版ステータスPublished - 2010
イベントPhotonic Therapeutics and Diagnostics VI - San Francisco, CA, United States
継続期間: 2010 1月 232010 1月 25


名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE


OtherPhotonic Therapeutics and Diagnostics VI
国/地域United States
CitySan Francisco, CA

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング


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