@article{d91d013e6a6a4d2ebf013a4bbdba6967,
title = "Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease",
abstract = "We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition activities of a new set of proline-type fullerene derivatives. All of the compounds had the potential to inhibit both the enzymes, indicating that the fullerene derivatives may be dual inhibitors against NS5B and NS3/4A and could be novel lead compounds for the treatment of HCV infections.",
keywords = "Fullerene, Hepatitis C virus (HCV), NS3/4A protease, NS5B polymerase",
author = "Hiroki Kataoka and Tomoyuki Ohe and Kyoko Takahashi and Shigeo Nakamura and Tadahiko Mashino",
note = "Funding Information: This work was supported by a Health Labor Sciences Research Grant from the Ministry of Health, Labor, and Welfare of Japan ( MHLW ) and by the Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( MEXT ). We thank Dr. Kumiko Shimotohno and Dr. Kunitada Shimotohno for their assistance and support in the preparation of NS5B polymerase. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.bmcl.2016.08.086",
language = "English",
volume = "26",
pages = "4565--4567",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "19",
}
