Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Shuhei Kosono; Akihiro Kasai; Sumika Komaba; Teruhiko Matsubara; Toshinori Sato; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/c8cc03865a

Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Shuhei Kosono, Akihiro Kasai, Sumika Komaba, Teruhiko Matsubara, Toshinori Sato, Daisuke Takahashi, Kazunobu Toshima

研究成果: Article › 査読

9 被引用数 (Scopus)

抄録

Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C₃-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

本文言語	English
ページ（範囲）	7467-7470
ページ数	4
ジャーナル	Chemical Communications
巻	54
号	54
DOI	https://doi.org/10.1039/c8cc03865a
出版ステータス	Published - 2018

ASJC Scopus subject areas

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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abstract = "Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.",

author = "Shuhei Kosono and Akihiro Kasai and Sumika Komaba and Teruhiko Matsubara and Toshinori Sato and Daisuke Takahashi and Kazunobu Toshima",

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T1 - Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

AU - Kosono, Shuhei

AU - Kasai, Akihiro

AU - Komaba, Sumika

AU - Matsubara, Teruhiko

AU - Sato, Toshinori

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

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Y1 - 2018

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Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

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