Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima; Kiyoshi Ohishi; Miho Tomishima; Shuichi Matsumura

doi:10.3987/COM-97-7777

Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima, Kiyoshi Ohishi, Miho Tomishima, Shuichi Matsumura

応用化学科

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

本文言語	English
ページ（範囲）	851-855
ページ数	5
ジャーナル	Heterocycles
巻	45
号	5
DOI	https://doi.org/10.3987/COM-97-7777
出版ステータス	Published - 1997 1月 1

ASJC Scopus subject areas

分析化学
薬理学
有機化学

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10.3987/COM-97-7777

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abstract = "The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.",

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AB - The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

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Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

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