Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom-Economical Asymmetric Catalysis

Naoya Kumagai, Masakatsu Shibasaki

研究成果: Review article査読

31 被引用数 (Scopus)

抄録

Recent advances in catalytic asymmetric carbon–carbon bond-forming reactions of non-heteroaromatic amide substrates are highlighted. Among carbonyl compounds, amides have received limited attention in catalytic asymmetric transformations mainly owing to their lower reactivity. Amides are reluctant to form enolates for nucleophilic addition, and α,β-unsaturated amides exhibit diminished electrophilicity at the β-carbon. Recent advances in asymmetric catalysis rendered these amides amenable to enantioselective reactions with perfect atom economy, producing synthetically useful chiral building blocks. This Minireview summarizes recent developments in the field.

本文言語English
ページ(範囲)15192-15200
ページ数9
ジャーナルChemistry - A European Journal
22
43
DOI
出版ステータスPublished - 2016 10月 17
外部発表はい

ASJC Scopus subject areas

  • 化学一般
  • 触媒
  • 有機化学

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