抄録
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such " oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 3652-3658 |
| ページ数 | 7 |
| ジャーナル | Journal of Clinical Investigation |
| 巻 | 123 |
| 号 | 9 |
| DOI | |
| 出版ステータス | Published - 2013 9月 3 |
ASJC Scopus subject areas
- 医学（全般）
