TY - JOUR
T1 - Oxidation of d-α-tocopherol in aqueous solution. Formation of colored products
AU - Nagata, Yoshiko
AU - Miyamoto, Chie
AU - Matsushima, Yoshikazu
AU - Matsumoto, Shigenobu
PY - 1999/7
Y1 - 1999/7
N2 - An aqueous solution of d-α-tocopherol solubilized with sodium deoxycholate became colored on standing, probably due to air oxidation. 5- Formyl-7,8-dimethyltocol (1) and 7-formyl-5,8-dimethyltocol (2) were isolated from the solution and concluded to be responsible for the coloration. In oxidation of aqueous solutions of d-α-tocopherol, the time course of formation of products was followed by analytical HPLC. The main oxidation product was 1 in solutions solubilized with sodium deoxycholate and sodium cholate, whereas α-tocoquinone was the main product in those solubilized with 2,6-di-O-methyl-β-cyclodextrin.
AB - An aqueous solution of d-α-tocopherol solubilized with sodium deoxycholate became colored on standing, probably due to air oxidation. 5- Formyl-7,8-dimethyltocol (1) and 7-formyl-5,8-dimethyltocol (2) were isolated from the solution and concluded to be responsible for the coloration. In oxidation of aqueous solutions of d-α-tocopherol, the time course of formation of products was followed by analytical HPLC. The main oxidation product was 1 in solutions solubilized with sodium deoxycholate and sodium cholate, whereas α-tocoquinone was the main product in those solubilized with 2,6-di-O-methyl-β-cyclodextrin.
KW - 5-formyl-7,8-dimethyltocol
KW - 7-formyl-5,8- dimethyltocol
KW - Sodium cholate
KW - Sodium deoxycholate
KW - d-α-tocopherol
KW - α-tocoquinone
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U2 - 10.1248/cpb.47.923
DO - 10.1248/cpb.47.923
M3 - Article
AN - SCOPUS:0032808846
SN - 0009-2363
VL - 47
SP - 923
EP - 927
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 7
ER -