P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall

Kaoru Ogawa, Jochen Schacht

研究成果: Article査読

23 被引用数 (Scopus)

抄録

THE tissues of the lateral wall of the cochlea, spiral ligament and stria vascularis, maintain homeostasis of the inner ear through the production of endolymph and regulation of cochlear blood flow. We examined the effects of purinergic agonists on the release of inositol phosphates (InsPs) in intact isolated lateral wall tissues of the Fischer-344 rat. After preincubation with myo- [3H]inositol, stimulation with the P2 purinergic agonist ATP-γ-S resulted in a concentration-dependent increase in the formation of [3H]InsPs. The P2 purinergic agonist α,β-methylene ATP (AMP-CPP) was a weaker stimulant, and the PI purinergic agonist adenosine was ineffective. These results are consistent with the presence of P2y receptors and a purinergically controlled InsP3 second messenger system in the cochlear lateral wall.

本文言語English
ページ(範囲)1538-1540
ページ数3
ジャーナルNeuroReport
6
11
DOI
出版ステータスPublished - 1995 7月

ASJC Scopus subject areas

  • 神経科学一般

フィンガープリント

「P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル