Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta; Takuro Maruyama; Minoru Nagahashi; Yasuyo Miyamoto; Shinzo Hosoi; Fumiyuki Kiuchi; Yasushi Yamazoe; Sachiko Tsukamoto

doi:10.1016/S0040-4020(02)00739-1

Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta
, Takuro Maruyama
, Minoru Nagahashi
, Yasuyo Miyamoto
, Shinzo Hosoi
, Fumiyuki Kiuchi
, Yasushi Yamazoe
, Sachiko Tsukamoto

研究成果: Article › 査読

54 被引用数 (Scopus)

抄録

A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

本文言語	English
ページ（範囲）	6631-6635
ページ数	5
ジャーナル	Tetrahedron
巻	58
号	33
DOI	https://doi.org/10.1016/S0040-4020(02)00739-1
出版ステータス	Published - 2002 8月 12
外部発表	はい

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/S0040-4020(02)00739-1

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title = "Paradisin C: A new CYP3A4 inhibitor from grapefruit juice",

abstract = "A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.",

keywords = "Absolute stereochemistry, CYP3A4 inhibition, Furanocoumarin, Grapefruit juice, Paradisin",

author = "Tomihisa Ohta and Takuro Maruyama and Minoru Nagahashi and Yasuyo Miyamoto and Shinzo Hosoi and Fumiyuki Kiuchi and Yasushi Yamazoe and Sachiko Tsukamoto",

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doi = "10.1016/S0040-4020(02)00739-1",

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T1 - Paradisin C

T2 - A new CYP3A4 inhibitor from grapefruit juice

AU - Ohta, Tomihisa

AU - Maruyama, Takuro

AU - Nagahashi, Minoru

AU - Miyamoto, Yasuyo

AU - Hosoi, Shinzo

AU - Kiuchi, Fumiyuki

AU - Yamazoe, Yasushi

AU - Tsukamoto, Sachiko

PY - 2002/8/12

Y1 - 2002/8/12

N2 - A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

AB - A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

KW - Absolute stereochemistry

KW - CYP3A4 inhibition

KW - Furanocoumarin

KW - Grapefruit juice

KW - Paradisin

UR - https://www.scopus.com/pages/publications/0037067849

UR - https://www.scopus.com/pages/publications/0037067849#tab=citedBy

U2 - 10.1016/S0040-4020(02)00739-1

DO - 10.1016/S0040-4020(02)00739-1

M3 - Article

AN - SCOPUS:0037067849

SN - 0040-4020

VL - 58

SP - 6631

EP - 6635

JO - Tetrahedron

JF - Tetrahedron

IS - 33

ER -

Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

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