Pathogenesis of CDK8-associated disorder: two patients with novel CDK8 variants and in vitro and in vivo functional analyses of the variants

Medicine & Life Sciences

• Cyclin-Dependent Kinase 8 100%
• Zebrafish 33%
• Phosphotransferases 25%
• In Vitro Techniques 22%
• human CDK8 protein 16%
• Alleles 14%
• Mediator Complex 10%
• Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8%
• Cyclins 7%
• Exome 7%
• Neurodevelopmental Disorders 7%
• Missense Mutation 6%
• Intellectual Disability 6%
• Virulence 5%
• Cultured Cells 5%
• Embryonic Structures 5%
• Psychological Inhibition 5%
• Genes 5%
• Heart 4%
• Phenotype 3%
• Mutation 3%
• Enzymes 3%