@inbook{7ee4260fb860408d947a3cf3c6304c9c,
title = "Peptide Toxins Targeting KV Channels",
abstract = "A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+ (KV) channels and are mainly classified into pore-blocking toxins or gating-modifier toxins. Pore-blocking toxins directly bind to the ion permeation pores of KV channels, thereby physically occluding them. In contrast, gating-modifier toxins bind to the voltage-sensor domains of KV channels, modulating their voltage-dependent conformational changes. These peptide toxins are useful molecular tools in revealing the structure-function relationship of KV channels and have potential for novel treatments for diseases related to KV channels. This review focuses on the inhibition mechanism of pore-blocking and gating-modifier toxins that target KV channels.",
keywords = "Gating-modifier toxin, Peptide toxin, Pore-blocking toxin, Voltage-gated potassium channel",
author = "Kazuki Matsumura and Mariko Yokogawa and Masanori Osawa",
note = "Funding Information: Acknowledgements All molecular graphics images were prepared using CueMol (http://www. cuemol.org). The authors are grateful to the Japan Society for the Promotion of Science KAKENHI Grant Numbers JP17H03978 and JP19H04973 (to M.O.), a grant from The Vehicle Racing Commemorative Foundation (to M.O.), and a grant from Takeda Science Foundation (to M.Y. and M.O.). Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/164_2021_500",
language = "English",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "481--505",
booktitle = "Handbook of Experimental Pharmacology",
}