Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction

Yusuke Yumita, Yuji Nagatomo, Makoto Takei, Mike Saji, Ayumi Goda, Takashi Kohno, Shintaro Nakano, Yosuke Nishihata, Yukinori Ikegami, Yasuyuki Shiraishi, Shun Kohsaka, Takeshi Adachi, Tsutomu Yoshikawa

研究成果: Article査読

2 被引用数 (Scopus)


The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (∆HR) from −10 to ±0 was associated with a lower risk of primary endpoint and ∆HR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies.

ジャーナルJournal of Personalized Medicine
出版ステータスPublished - 2022 1月

ASJC Scopus subject areas

  • 医学(その他)


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