TY - JOUR
T1 - Peyer's patch organogenesis as a programmed inflammation
T2 - A hypothetical model
AU - Nishikawa, Shin Ichi
AU - Nishikawa, Satomi
AU - Honda, Kenya
AU - Hashi, Hiroyuki
AU - Yoshida, Hisahiro
N1 - Funding Information:
Acknowledgements:This study is supported by grants from the Ministry of Education, Science, Sports and Culture of Japan (Nos 07CE2005, 06277102 and 06NP1101).
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.
AB - Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.
KW - GALT (gut associated lymphoid tissue)
KW - IL-7 receptor
KW - Inflammation
KW - Lymphotoxin
KW - Peripheral lymphoid tissue
KW - Peyer's patch
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U2 - 10.1016/S1359-6101(98)00014-8
DO - 10.1016/S1359-6101(98)00014-8
M3 - Short survey
C2 - 9918121
AN - SCOPUS:0344527964
SN - 1359-6101
VL - 9
SP - 213
EP - 220
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 3-4
ER -
