Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial

Hiroki Nagashima, Rintaro Mikata, Shiroh Isono, Sadahisa Ogasawara, Harutoshi Sugiyama, Izumi Ohno, Shin Yasui, Tomoaki Matsumura, Keisuke Koroki, Yuko Kusakabe, Yoshifumi Miura, Motoyasu Kan, Shikiko Maruta, Toshihito Yamada, Ryo Takemura, Yasunori Sato, Jun Kato, Naoya Kato

研究成果: Article査読

抄録

Nasal pressure signal is commonly used to evaluate obstructive sleep apnea. This study aimed to assess its safety for respiratory monitoring during sedation. A total of 45 adult patients undergoing sedation with propofol and fentanyl for invasive endoscopic procedures were enrolled. While both nasal pressure and capnograph signals were continuously recorded, only the nasal pressure signal was displayed. The primary outcome was the incidence of oxygen desaturation below 90%. The secondary outcomes were the ability to predict the desaturation and incidence of harmful events and false alarms, defined as an apnea waveform lasting more than 3 min without desaturation. Of the 45 participants, 43 completed the study. At least one desaturation event occurred in 12 patients (27.9%; 95% confidence interval 15.3–43.7%). In these 12 patients, more than half of the desaturation events were predictable in 9 patients by capnography and 11 patients by nasal pressure monitoring (p = 0.59). In the 43 patients, false alarms were detected in 7 patients with capnography and 11 patients with nasal pressure monitoring (p = 0.427). Harmful events unrelated to nasal pressure monitoring occurred in 2 patients. Nasal pressure monitoring is safe and possibly useful for respiratory monitoring despite false alarms during sedation.

本文言語English
論文番号1265
ジャーナルScientific reports
13
1
DOI
出版ステータスPublished - 2023 12月

ASJC Scopus subject areas

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