Physical frailty in older people with severe aortic stenosis

Shogo Fukui, Michiyuki Kawakami, Yohei Otaka, Aiko Ishikawa, Katsuhiro Mizuno, Tetsuya Tsuji, Kentaro Hayashida, Taku Inohara, Fumiaki Yashima, Meigen Liu

研究成果: Article査読

17 被引用数 (Scopus)


Background: Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. Aims: We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. Methods: A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty. Results: Physical frailty was prevalent in 38.4 %. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 % decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01). Conclusions: The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.

ジャーナルAging Clinical and Experimental Research
出版ステータスPublished - 2016 12月 1

ASJC Scopus subject areas

  • 加齢科学
  • 老年医学


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