Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Takeshi Suzuki, Ryoichi Takagi, Koichiro Kawashima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA A receptor stimulation and the associated increase in Cl- conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABAA receptor Cl- channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl- channel increases neuronal excitability even in an early stage of the development.

本文言語English
ページ(範囲)57-60
ページ数4
ジャーナルNeuroscience Letters
356
1
DOI
出版ステータスPublished - 2004 2月 6

ASJC Scopus subject areas

  • 神経科学一般

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