Plant extracts induce chromosome aberrations and sister-chromatid exchanges in Chinese hamster ovary cells and human lymphocytes

Nobuhiro Kanaya; Shin Takehisa; Hristo Nicoloff; Teodora Nikolova; Vihra Damianova

doi:10.1016/0165-7992(92)90035-G

Plant extracts induce chromosome aberrations and sister-chromatid exchanges in Chinese hamster ovary cells and human lymphocytes

Nobuhiro Kanaya, Shin Takehisa, Hristo Nicoloff, Teodora Nikolova, Vihra Damianova

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研究成果: Article › 査読

6 被引用数 (Scopus)

抄録

Effects of extracts from Vicia faba were compared with those of Zea mays for the induction of sister-chromatid exchanges (SCEs) and of chromosome aberrations (CAs) in Chinese hamster ovary (CHO) cells. CA induction by the maize extract was also tested in human lymphocytes. The extracts from roots and leaves of Vicia faba induced CAs and SCEs in CHO cells. The extracts from maize leaves also induced SCEs and CAs in CHO cells, and CAs in human lymphocytes. Maize extracts were more potent in inducing SCEs than Vicia extracts and the SCE- and CA-inducing capacity of maize extracts decreased during preincubation before addition to cells.

本文言語	English
ページ（範囲）	47-54
ページ数	8
ジャーナル	Mutation Research Letters
巻	281
号	1
DOI	https://doi.org/10.1016/0165-7992(92)90035-G
出版ステータス	Published - 1992 1月

ASJC Scopus subject areas

医学（全般）

UN SDG

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10.1016/0165-7992(92)90035-G

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引用スタイル

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title = "Plant extracts induce chromosome aberrations and sister-chromatid exchanges in Chinese hamster ovary cells and human lymphocytes",

abstract = "Effects of extracts from Vicia faba were compared with those of Zea mays for the induction of sister-chromatid exchanges (SCEs) and of chromosome aberrations (CAs) in Chinese hamster ovary (CHO) cells. CA induction by the maize extract was also tested in human lymphocytes. The extracts from roots and leaves of Vicia faba induced CAs and SCEs in CHO cells. The extracts from maize leaves also induced SCEs and CAs in CHO cells, and CAs in human lymphocytes. Maize extracts were more potent in inducing SCEs than Vicia extracts and the SCE- and CA-inducing capacity of maize extracts decreased during preincubation before addition to cells.",

keywords = "CHO cells, Chromosome aberrations, Human lymphocytes, Plant extracts, Sister-chromatid exchanges",

author = "Nobuhiro Kanaya and Shin Takehisa and Hristo Nicoloff and Teodora Nikolova and Vihra Damianova",

note = "Funding Information: This work was in part supported by grants from the Japan Society for the Promotion of Science (to S.T.) and from Keio University (to N.K. and S.T.). Thanks also go to Prof. Dr. Rigo-",

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T1 - Plant extracts induce chromosome aberrations and sister-chromatid exchanges in Chinese hamster ovary cells and human lymphocytes

AU - Kanaya, Nobuhiro

AU - Takehisa, Shin

AU - Nicoloff, Hristo

AU - Nikolova, Teodora

AU - Damianova, Vihra

N1 - Funding Information: This work was in part supported by grants from the Japan Society for the Promotion of Science (to S.T.) and from Keio University (to N.K. and S.T.). Thanks also go to Prof. Dr. Rigo-

PY - 1992/1

Y1 - 1992/1

N2 - Effects of extracts from Vicia faba were compared with those of Zea mays for the induction of sister-chromatid exchanges (SCEs) and of chromosome aberrations (CAs) in Chinese hamster ovary (CHO) cells. CA induction by the maize extract was also tested in human lymphocytes. The extracts from roots and leaves of Vicia faba induced CAs and SCEs in CHO cells. The extracts from maize leaves also induced SCEs and CAs in CHO cells, and CAs in human lymphocytes. Maize extracts were more potent in inducing SCEs than Vicia extracts and the SCE- and CA-inducing capacity of maize extracts decreased during preincubation before addition to cells.

AB - Effects of extracts from Vicia faba were compared with those of Zea mays for the induction of sister-chromatid exchanges (SCEs) and of chromosome aberrations (CAs) in Chinese hamster ovary (CHO) cells. CA induction by the maize extract was also tested in human lymphocytes. The extracts from roots and leaves of Vicia faba induced CAs and SCEs in CHO cells. The extracts from maize leaves also induced SCEs and CAs in CHO cells, and CAs in human lymphocytes. Maize extracts were more potent in inducing SCEs than Vicia extracts and the SCE- and CA-inducing capacity of maize extracts decreased during preincubation before addition to cells.

KW - CHO cells

KW - Chromosome aberrations

KW - Human lymphocytes

KW - Plant extracts

KW - Sister-chromatid exchanges

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JO - Mutation Research Letters

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