Polymorphism of Tau Fibrils

研究成果: Chapter

抄録

Tau is a protein that binds and stabilizes microtubules as a physiologic function, but it is also well known as a protein that forms insoluble and fibrillar aggregates in neurodegenerative diseases called tauopathies. Notably, pathologic Tau fibrils exhibit various morphologies that are associated with particular subtypes of tauopathies. Distinct symptoms among tauopathies could thus be regulated by the morphology/structure of Tau fibrils, but the exact mechanism by which such polymorphism arises in Tau fibrils remains unknown. In this chapter, to help the reader understand possible roles of polymorphic Tau fibrils in the pathomechanism of neurodegenerative diseases, I review and summarize several factors affecting the morphologies of Tau fibrils in vitro.

本文言語English
ホスト出版物のタイトルBio-nanoimaging
ホスト出版物のサブタイトルProtein Misfolding and Aggregation
出版社Elsevier Inc.
ページ213-222
ページ数10
ISBN(印刷版)9780123944313
DOI
出版ステータスPublished - 2013 11月

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

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