TY - JOUR
T1 - Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram
AU - Umezawa, Akihiro
AU - Yamada, Taketo
AU - Ogawa, Yuuto
AU - Kuramochi, Shigeru
AU - Watanabe, Yonosuke
PY - 1990/9
Y1 - 1990/9
N2 - An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.
AB - An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.
KW - Acute megakaryocytic leukemia
KW - Glycoprotein IIb/IIIa
KW - Immunohistochemistry
KW - Tissue hemogram
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U2 - 10.1111/j.1440-1827.1990.tb01618.x
DO - 10.1111/j.1440-1827.1990.tb01618.x
M3 - Article
C2 - 2260477
AN - SCOPUS:0025155217
SN - 1320-5463
VL - 40
SP - 693
EP - 698
JO - Pathology international
JF - Pathology international
IS - 9
ER -