Potential role of angiotensin receptor antagonists in renal protection

K. Hayashi, H. Matsuda, M. Honda, T. Saruta

研究成果: Review article査読


Recent clinical studies have established an important role of angiotensin converting enzyme inhibitors (ACE-I) as a tool for renal protection. Although angiotensin receptor antagonists (AII-A) share the common property with ACE-I with regard to blockade of angiotensin activity via angiotensin type 1 receptors (AT1), AII-A is also reported to stimulate AT2 that plausibly activates nitric oxide production within renal medulla and augments synthesis of vasodilatory P450-metabolites in renal afferent arterioles. In contrast, AII-A is reported to have no effect on bradykinin activity. Results obtained in experimental animals indicate that AII-A effectively prevents the progression of renal injury. Several clinical studies are in progress, and the preliminary results suggest that AII-A has potent renal protective action in a variety of renal disorders.

ジャーナルNippon rinsho. Japanese journal of clinical medicine
出版ステータスPublished - 1999 5月

ASJC Scopus subject areas

  • 医学一般


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