Prediction of myocardial damage depth induced by extracellular photosensitization reaction using fluorescence measurement in vivo

M. Takahashi, E. Ogawa, T. Nakamura, H. Kawakami, N. Machida, M. Yajima, M. Kurotsu, A. Ito, T. Kimura, Tsunenori Arai

研究成果: Conference contribution


We experimentally studied the correlation between myocardial damage depth due to the extracellular photosensitization reaction (PR) using talaporfin sodium and fluorescence-fall amount (FA), which is calculated from the measured backscattering fluorescence intensity via a manipulatable 7 Fr. laser catheter during the PR operation in vivo to establish treatment depth predictor for a non-thermal tachyarrhythmia treatment. The PR was performed to left and/or right ventricle in the open-chest canine heart. The laser irradiation of 663±2 nm in wavelength via the laser catheter was operated 15 min after the intravenous administration of talaporfin sodium with concentration of 36.2±8.0 μg/ml in plasma. The irradiation was operated with irradiance of 5, 10, 20 W/cm2, and duration of 5, 10, 20 s. Backscattering fluorescence of 710±2 nm in wavelength was measured via the laser catheter during the PR. The FA was calculated multiplying the irradiation duration by the fluorescence-fall, which is subtraction of the fluorescence intensity at the kickoff and end of the irradiation. The canine heart was extracted 1 week after the PR and HE stained specimen was histologically evaluated. The correlation of the myocardial damage depth and FA was investigated. We found that FA obtained a logarithmic relation to the myocardial damage depth. We think that the FA might be available to predict the PR induced myocardial damage depth for the application of tachyarrhythmia treatment under catheterization in vivo.

ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics X
出版ステータスPublished - 2014
イベントPhotonic Therapeutics and Diagnostics X - San Francisco, CA, United States
継続期間: 2014 2月 12014 2月 2


名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE


OtherPhotonic Therapeutics and Diagnostics X
国/地域United States
CitySan Francisco, CA

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング


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