Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT

M. Sato, H. Nakasone, K. Oshima, Y. Ishihara, H. Wada, K. Sakamoto, K. Kawamura, M. Ashizawa, T. MacHishima, K. Terasako, S. Kimura, M. Kikuchi, S. Okuda, A. Tanihara, R. Yamazaki, Y. Tanaka, J. Kanda, S. Kako, J. Nishida, Y. Kanda

研究成果: Article査読

29 被引用数 (Scopus)


Various biomarkers have been investigated with regard to their ability to predict the outcome of allogeneic hematopoietic SCT (HSCT). In this study, we retrospectively reviewed 90 recipients who received HSCT between 2007 and 2011 in our institution, and evaluated the predictive value of the baseline serum C-reactive protein (CRP) levels just before the initiation of conditioning for transplant-related complications after allogeneic HSCT. A receiver-operating characteristic curve revealed that the baseline serum CRP levels had an excellent predictive value for non-relapse mortality (NRM), with an area under the curve of 0.83. The sensitivity and specificity for NRM were 80% and 87%, respectively, with a cutoff of 0.6 mg/dL. With this cutoff value, multivariate analyses revealed that a higher baseline CRP level was an independent risk factor for NRM (HR 6.21, P<0.01), grade III-IV acute GVHD (HR 3.91, P=0.03) and poor overall survival (HR 3.27, P=0.0018). On the other hand, the baseline CRP level did not predict infectious events. These findings suggested that CRP levels before conditioning may be a useful predictive biomarker for poor survival.

ジャーナルBone Marrow Transplantation
出版ステータスPublished - 2013 5月

ASJC Scopus subject areas

  • 血液学
  • 移植


「Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。