Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa; Yoshikiyo Akasaka; Toshio Kanai; Yoshihide Otani; Koichiro Kumai; Tetsuro Kubota; Masaki Kitajima

doi:10.3892/or.10.2.381

Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa, Yoshikiyo Akasaka, Toshio Kanai, Yoshihide Otani, Koichiro Kumai, Tetsuro Kubota, Masaki Kitajima

研究成果: Article › 査読

19 被引用数 (Scopus)

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We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

本文言語	English
ページ（範囲）	381-386
ページ数	6
ジャーナル	Oncology reports
巻	10
号	2
DOI	https://doi.org/10.3892/or.10.2.381
出版ステータス	Published - 2003 3月
外部発表	はい

ASJC Scopus subject areas

腫瘍学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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title = "Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma",

abstract = "We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.",

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T1 - Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

AU - Saikawa, Yoshiro

AU - Akasaka, Yoshikiyo

AU - Kanai, Toshio

AU - Otani, Yoshihide

AU - Kumai, Koichiro

AU - Kubota, Tetsuro

AU - Kitajima, Masaki

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AB - We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

KW - Cisplatin

KW - Gastric cancer

KW - Preoperative chemotherapy

KW - S-1

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Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

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ASJC Scopus subject areas

UN SDG

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