Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

Taiko Oda; Yoshihiro Sato

doi:10.1248/cpb.41.1856

Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

Taiko Oda, Yoshihiro Sato

薬学科

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

本文言語	English
ページ（範囲）	1856-1859
ページ数	4
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	41
号	10
DOI	https://doi.org/10.1248/cpb.41.1856
出版ステータス	Published - 1993 1月 1

ASJC Scopus subject areas

化学 (全般)
創薬

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10.1248/cpb.41.1856

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abstract = "In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.",

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author = "Taiko Oda and Yoshihiro Sato",

year = "1993",

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AU - Oda, Taiko

AU - Sato, Yoshihiro

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N2 - In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

AB - In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

KW - circular dichroism

KW - indenestrol A monomethyl ether

KW - indenestrol B monomethyl ether

KW - optical resolution

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JO - Chemical and Pharmaceutical Bulletin

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Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

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