抄録
To clarify the presence and origin of acetylcholine (ACh) in human blood, the ACh contents of whole blood, mononuclear (MNL) and polymorphonuclear leukocytes (PMN) were determined by a sensitive, specific radioimmunoassay. The mean (± S.E.M.) ACh contents of whole blood and MNL measured in 30 normal subjects were 1263.5 ± 149.0 and 731.0 ± 85.8 pg/ml blood, respectively. A significant correlation was observed between the ACh content of whole blood and that of MNL (r = 0.91; P < 0.001). No detectable ACh was present in PMN. These results demonstrate that ACh is present in human blood, and indicate that the major portion of plasma ACh originates from circulating MNL.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 251-258 |
| ページ数 | 8 |
| ジャーナル | Biogenic Amines |
| 巻 | 9 |
| 号 | 4 |
| 出版ステータス | Published - 1993 1月 1 |
ASJC Scopus subject areas
- 神経科学（全般）
- 薬理学