Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma

Takuya Mikoshiba, Hiroyuki Ozawa, Yoshihiro Watanabe, Miho Kawaida, Mariko Sekimizu, Shin Saito, Keisuke Yoshihama, Shintaro Nakamura, Ryoto Nagai, Yorihisa Imanishi, Kaori Kameyama, Kaoru Ogawa

研究成果: Article査読

2 被引用数 (Scopus)


Objective: The histological grade of parotid gland carcinoma (PGC) is an important prognostic factor; however, the diagnosis prior to treatment has been challenging to make. This study aimed to investigate whether the pretreatment clinical findings, including hematological inflammatory, nutritional, and immune markers, could predict the histological grade of PGC. Study Design: Retrospective study. Methods: We retrospectively enrolled 111 patients with PGC and evaluated the correlation between histological grade and pretreatment clinical findings such as age, sex, tumor staging, facial nerve paralysis, pain or tenderness, adhesion to the surrounding tissues or tumor immobility, and hematological markers. Results: Sixty patients (54%) were diagnosed with histological high-grade PGC. Univariate analysis revealed that age, T classification, N classification, TNM stage, facial nerve paralysis, adhesion/immobility, C-reactive protein (CRP), and CRP-to-albumin ratio (CAR) were significant predictors of PGC histological grade. On multivariate analysis, high T classification (T3, 4), high N classification (≥1), and elevated CRP (≥0.22 mg/dL) were independent predictors of high-grade PGC. Conclusions: Pretreatment T classification, N classification, and CRP are significant predictors of the histological grading of PGC. Our results are useful for treatment planning and obtaining appropriate informed consent from the patients before treatment. Level of Evidence: 4 Laryngoscope, 132:96–102, 2022.

出版ステータスPublished - 2022 1月

ASJC Scopus subject areas

  • 耳鼻咽喉科学


「Pretherapeutic Predictive Factors for Histological High-Grade Parotid Gland Carcinoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。