TY - JOUR
T1 - Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
AU - Nishi, Kotaro
AU - Iwai, Satomi
AU - Tajima, Kazuki
AU - Okano, Shozo
AU - Sano, Motoaki
AU - Kobayashi, Eiji
N1 - Funding Information:
This work was supported by grants from Doctors Man Co., who had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript (Grant number: 2225-7257, 2225-7265).
Funding Information:
This work was supported by grants from Doctors Man Co., Ltd. Sou Hashimoto from this company assisted with devising the system for infusing hydrogen gas into organs as preservation solution.
Publisher Copyright:
© Copyright © 2021 Nishi, Iwai, Tajima, Okano, Sano and Kobayashi.
PY - 2021/2/17
Y1 - 2021/2/17
N2 - In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the present study, we verified the impact of hydrogen gas treatment in transplantation with the optimal immunosuppressive protocol based on human clinical setting by using the miniature pig model. Marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal vasculitis. We concluded that marginal kidney graft from donor after cardiac death is an acceptable model for chronic rejection and that if the transplantation is carried out using a strict immunosuppressive protocol, chronic rejection may be alleviated even with the marginal kidney.
AB - In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the present study, we verified the impact of hydrogen gas treatment in transplantation with the optimal immunosuppressive protocol based on human clinical setting by using the miniature pig model. Marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal vasculitis. We concluded that marginal kidney graft from donor after cardiac death is an acceptable model for chronic rejection and that if the transplantation is carried out using a strict immunosuppressive protocol, chronic rejection may be alleviated even with the marginal kidney.
KW - chronic allograft nephropathy
KW - chronic rejection
KW - hydrogen-containing organ preservation solution
KW - kidney transplantation
KW - marginal donor
KW - mature minipig model
KW - multi-immunosuppressant
UR - http://www.scopus.com/inward/record.url?scp=85102005226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102005226&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.626295
DO - 10.3389/fimmu.2020.626295
M3 - Article
C2 - 33679720
AN - SCOPUS:85102005226
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 626295
ER -