Prognostic significance of dysadherin expression in tongue cancer: Immunohistochemical analysis of 91 cases

Yukihiro Nakanishi, Shingo Akimoto, Yasuto Sato, Yae Kanai, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article査読

38 被引用数 (Scopus)

抄録

The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently we have reported a novel cell membrane glycoprotein, dysadherin, which has an anticell-cell adhesion function and downregulates E-cadherin. Expressions of dysadherin and E-cadherin were investigated immunohistochemically in 91 patients with squamous cell carcinoma of the tongue to determine the correlation between the 2 molecules and their associations with the clinicopathologic features of the tumors and with patient survival. Dysadherin was expressed at the cell membranes of many cancer cells: Twenty-five percent of the tumors showed dysadherin immunopositivity in more than 50% of the cancer cells. Sixty-nine percent of the tumors showed reduced E-cadherin immunopositivity. There was an inverse correlation between dysadherin expression and E-cadherin expression (P = 0.0001). Increased dysadherin expression was significantly correlated with an infiltrative type of growth pattern (P = 0.001), high tumor-node-metastasis (TNM) stage (P = 0.024), and poor patient survival (P = 0.003). After adjusting for growth pattern, TNM stage, and other clinicopathologic features, increased dysadherin expression and reduced E-cadherin expression were both significant predictors of poor survival (P = 0.0006). Increased dysadherin expression is a significant indicator of poor prognosis in patients with squamous cell carcinoma of the tongue.

本文言語English
ページ(範囲)323-328
ページ数6
ジャーナルApplied Immunohistochemistry and Molecular Morphology
12
4
DOI
出版ステータスPublished - 2004 12月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学
  • 医療検査技術

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