TY - JOUR
T1 - Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier
AU - Mizuno, Shinta
AU - Yamagishi, Yoshiyuki
AU - Ebinuma, Hirotoshi
AU - Nakamoto, Nobuhiro
AU - Katahira, Mai
AU - Sasaki, Aya
AU - Sakamoto, Michiie
AU - Suzuki, Hidekazu
AU - Kanai, Takanori
AU - Hibi, Toshifumi
PY - 2013/4
Y1 - 2013/4
N2 - A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers.
AB - A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers.
KW - Everolimus
KW - Hepatitis B virus
KW - Immunosuppressive therapy
KW - Liver failure
KW - Nucleoside analogue
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U2 - 10.1007/s12328-013-0371-4
DO - 10.1007/s12328-013-0371-4
M3 - Article
AN - SCOPUS:84902661548
SN - 1865-7257
VL - 6
SP - 188
EP - 192
JO - Clinical journal of gastroenterology
JF - Clinical journal of gastroenterology
IS - 2
ER -
